WebDec 19, 2024 · A simple, room temperature approach for the fast single-step synthesis of α-phosphonyloxy ketone, a drug scaffold, has been developed which involves highly reactive species i.e., 1,2-dicarbonyls that readily react with trialkyl phosphites and formic acids in batch as well as in continuous-flow with the flow rate of 3 ml/min ( = ∼4 s). WebFeb 8, 2016 · Coupling of α-ketoesters with imines initiated by diethyl phosphite in the presence of alkaline metal hexamethyldisilazides is reported. Base-promoted addition of diethyl phosphite to α-ketoesters, followed by [1,2]-phosphonate/phosphate rearrangement, generates α-phosphonyloxy enolates that are subsequently intercepted by imines.

Catalytic Enantioselective Protonation of α‐Oxygenated Ester …

WebIn recent years, para -quinone methides ( p -QMs) have emerged as attractive and versatile synthons in organic synthesis owing to their high reactivity. Consequently, p -QM … WebAfter 15 minutes, Diphenylphosphinyl aldimine (0.20 mmol, 1.0 equiv) in 1.0 mL THF was added dropwise to the solution via syringe. After another 15 minutes at −40 °C, the reaction was allowed to stir at room temperature for 2h. Then, the reaction was quenched with saturated aqueous ammonium chloride and extracted with ethyl acetate (3 times). dying wallpaper

Diethyl Phosphite-Initiated Coupling of α-Ketoesters with …

Web3-Ammonio-2-(phosphonyloxy)propane C3H10NO3P+2 CID 101624633 - structure, chemical names, physical and chemical properties, classification, patents, literature ... WebBase-promoted addition of diethyl phosphite to α-ketoesters, followed by [1,2]-phosphonate/phosphate rearrangement, generates α-phosphonyloxy enolates that are … WebMolecular Formula. C10H16NO3P+2. Synonyms. 3-Ammonio-4-phenyl-2- (phosphonyloxy)butane. Molecular Weight. 229.21. Parent Compound. CID 101624649 ( … dying virgin hair