Epha2 ihc
WebApr 14, 2024 · IHC staining of primary melanoma specimens revealed that EphA2-high/ephrinA1-low patients exhibited poorer outcomes than EphA2-high/ephrinA1-high patients. Conclusions From our data we conclude that evaluation of ephrinA1 levels may be helpful for the application of EphA2-targeted therapies and for prognostic predictions in … WebIn direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) EphA2 is observed, and less than 1% cross‑reactivity with rhEphA1, recombinant mouse (rm) EphA3, rmEphA4, rmEphA6, rmEphA7, rmEphA8, and recombinant rat EphA5 is observed. Source Polyclonal Goat IgG Purification Antigen Affinity-purified Immunogen
Epha2 ihc
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WebAug 27, 2024 · Moreover, western blotting and immunohistochemistry (IHC) showed that EphA2-WT increased the levels of p-Shp2 and p-Erk-1/2 in the xenografts of NPC cells, ... WebFeb 23, 2024 · Previous studies showed that phosphorylation at the juxtamembrane domain tyrosine 588 of EphA2 (Y588) is essential for its signaling activity (Binns et al., 2000; Fang et al., 2008).To explore the role of EphA2 signaling in HCC, we performed Y588 p-EphA2 and total EphA2 immunohistochemistry (IHC) on tissue microarrays from a retrospective …
WebEphA2 Antibody (PA5-14574) in IHC (P) Immunohistochemical analysis of formalin-fixed, paraffin-embedded human cancer tissue using an EphA2 polyclonal antibody ( Product # … WebJun 22, 2024 · New translational data for BT5528, a second-generation Bicycle Toxin Conjugate (BTC) that targets EphA2, describe the development of Bicycle’s proprietary IHC assay. This assay will be used to ...
WebMar 1, 2024 · IHC showed that EphA2-WT significantly increased the expression levels of c-Myc and Sox-2 in the lung metastases of NPC cells, whereas EphA2-SA failed to do it as compared to endogenous EphA2 knockdown (Fig. 6 C). These results suggest that Sox-2 and c-Myc are the effectors of pS897-EphA2-promoting NPC cell invasion and stem … WebThe receptor tyrosine kinase, ephrin type-A receptor 2 (EphA2) was found to be overexpressed in several malignancies and its expression was found to be associated with poor prognostic features. ... EphA2 = ephrin type-A receptor 2, IHC = immunohistochemical, OS = overall survival, RCC = renal cell carcinoma. How to cite this article: Talaat IM ...
WebNov 1, 2024 · GC patients with amplification (copy number >6) or overexpression (IHC 3+) of EGFR/HER2 were most likely to benefit from afatinib treatment and EPHA2 blockade reversed acquired resistance to afatinib treatment, which could provide solid evidences for future clinical trials.
WebAug 15, 2024 · EphA2 is an attractive tumor target; overexpression has been reported in multiple tumor types. Preclinical activity of BT5528 has been described previously, demonstrating increased efficacy is... barakat burhan hotelEphA2 protein expression was analysed by immunohistochemical (IHC) staining of formalin-fixed paraffin embedded (FFPE) tissues derived from a cohort of paediatric sarcoma biopsies, assembled in ... barakat cameraWebThe human EphA2 cDNA encodes a 976 amino acid (aa) precursor including a 24 aa signal sequence, a 510 aa extracellular domain (ECD), a 24 aa transmembrane segment, and a … barakat boltonWebTo explore the role of EphA2 signaling in HCC, we performed Y588 p-EphA2 and total EphA2 immunohistochemistry (IHC) on tissue microarrays from a retrospective cohort of 153 HCC specimens and 63 non-tumor liver tissues ().Y588 p-EphA2 and total EphA2 protein levels were assessed by a hepatic pathologist blinded to the patient outcome (Figures 1A … barakat camerounWebFeb 24, 2024 · EphA2 Antibody (C-3) is an IgG 2b κ mouse monoclonal EphA2 antibody (also designated Eph receptor A2 antibody, or Epithelial cell kinase antibody) suitable for … barakat businessWebFeb 12, 2024 · EphA2 Antibodies. Antibodies that detect EphA2 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Flow … barakat careers uaeWebJan 1, 2012 · However, the EphA2 protein expression, as assessed by IHC, may be disconnected from the RNA profile: Although kidney only has modest RNA expression, it showed the strongest staining in EphA2 IHC. Tissues with the highest RNA levels, such as lung or colon, only showed relatively light staining . Therefore there exists a nonlinear … barakat concrete