Cytoglobin function

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August undefined, 2024

WebMay 16, 2024 · Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress ( Trent and Hargrove, 2002 ). Cloning and Expression WebApr 27, 2016 · Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons. Here we provide, using immunohistochemistry, a …

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WebMost known globins fulfill respiratory functions, supplying the cell with adequate amounts of O 2 for aerobic energy production via the respiratory chain in the mitochondria [5–7]. ... [16–18] and is now officially named cytoglobin (Cygb), based on its widespread expression in many mammalian tissues and organs. WebDec 28, 2024 · Cytoglobin (Cygb) was discovered as a novel type of globin that is expressed in mammals; however, its functions remain uncertain. While Cygb protects … how to switch default google account

(PDF) Cytoglobin: A Novel Globin Type Ubiquitously Expressed ...

WebMar 15, 2011 · Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein. Its function is unknown and studies on the effects of changes in its expression … WebOct 13, 2024 · Cytoglobin has potent superoxide dismutase function. TGF-beta1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma. WebNeuroglobin and cytoglobin, members of the globin family, are present in vertebrate cells at very low concentrations. As the function of both proteins is still a matter of debate, it is very important to be able to produce and purify these proteins, and in general all members of the globin family, to homogeneity. how to switch dd1 to pc mode

Cytoglobin: biochemical, functional and clinical …

RCSB PDB - 1UMO: The crystal structure of cytoglobin: the fourth …

WebThe globin family includes eight different types of globins, but the best described and characterized in vertebrates are hemoglobin (Hb), myoglobin (Mb), cytoglobin (Cygb), … WebJul 9, 2011 · Recently, Cygb has been shown to inhibit cancer cell growth in vitro, thus confirming its suggested tumour suppressor role. This article aims to review the … how to switch contacts to new iphoneWebJul 9, 2011 · Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons. how to switch desks

"Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or reactive oxygen species, or serve a protective function during oxidative stress. See more Cytoglobin is the protein product of CYGB, a human and mammalian gene. Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001 … See more CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver. See more • cytoglobin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more • Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). "Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells". The Journal of … See more " - Cytoglobin function

Cytoglobin function

Myoglobin: What It Is, Function, Test & Results

WebMar 31, 2024 · cytoglobin antioxidant function relied on the same reductive pathway and did not recruit and was not reliant on alternate pathways. The ability of cytoglobin to … WebCytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O 2 reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb)). While Cgb is expressed in various tissues, its physiological role is not clearly understood. Here, the X-ray crystal structure of wild type …

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WebUsing independently derived antibodies, both report that Cygb is cytoplasmatically expressed in fibroblasts and fibroblast-related cell types in a broad variety of … WebSep 9, 2008 · The exact function of CYGB is unknown, although it has been proposed to play a role in collagen synthesis (22, 23), O 2 sensing and transport , or detoxification of …

WebMay 20, 2013 · Background. Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. Methods. We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) in 88 … WebWe identified a novel function of cytoglobin (Cygb) as an efficient superoxide dismutase (SOD) with a high–bimolecular dismutation rate on the order of 10 8 M −1 ⋅ s −1. It is the …

WebAbstact. Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region … WebMay 1, 2002 · Cytoglobin (Cygb) is a low expression hexacoordinate globin found in all tissues of vertebrates [1]. Despite effort to assign a biological role to Cygb, the function of this protein is not...

WebDec 28, 2024 · Abstract Cytoglobin (Cygb) was discovered as a novel type of globin that is expressed in mammals; however, its functions remain uncertain. While Cygb protects against oxidant stress, the basis for this is unclear, and the effect of Cygb on superoxide metabolism is unknown.

WebMay 15, 2009 · It is unlikely that Cygb functions in O 2 supply to the respiratory chain, but it may be involved in detoxification of reactive oxygen or nitrogen species (ROS/RNS),or in … how to switch date and month in excelWebDec 7, 2016 · Cytoglobin (Cygb), identified as a new globin family member protein, is expressed in various tissues. Although its interaction with oxygen and nitric oxide indicates the potential role in antioxidant pathways, the exact role remains unclear. ... Cygb could serve an O 2 scavenging and supplying function, and could contribute to the ... how to switch creative mode minecraftWebApr 10, 2024 · Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates... how to switch data from android to iphoneWebAug 26, 2003 · Cytoglobin is a recently discovered hemeprotein belonging to the globin superfamily together with hemoglobin, myoglobin and neuroglobin. Although distributed … how to switch computer to tv screenWebApr 15, 2013 · Cytoglobin (CYGB) is frequently downregulated in many types of human malignancies, and its exogenous overexpression reduces proliferation of cancer cells. Despite its implied tumour suppressor (TSG) functions, its exact role in carcinogenesis remains unclear as CYGB upregulation is also associated with tumour hypoxia and … how to switch default searchWebCytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region 17q25, which is frequently lost in multiple malignancies. Previous studies failed to detect evidence for mutations in the CYGB gene. Recent studies provided preliminary evidence for increased ... how to switch default browser to chrome how to switch directory in azure cli