WebHydrolysis of cisplatin Working species • synthesis • reactivity Anticancer metal complexes cisplatin(顺铂) From by chance to structure based exploration Discoverer of Anticancer Activity of Cisplatin • drug concentration and accumulation • effects on cell life • cell resistance • toxicity • cancer spectrum Cell responds to ... WebMar 24, 2003 · Cisplatin is administered to patients i.v. The physiological chloride concentration in blood and extracellular body fluids is 100 mM, which is high enough to …

How do I solubilize a high concentration of Cisplatin?

WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, … WebRusso and co-authors compared the energy barriers of AP-1′s and cisplatin’s hydrolysis processes and found that the hydrolysis of AP-1 is more favorable . Depending on the basis set used for DFT calculations, the activation barriers for hydrolysis of cisplatin are in the 25 kcal/mol–30 kcal/mol range [51,57]. The higher cytotoxic ... tsc car battery

Microneedle‐assisted transdermal delivery of nanoparticles: Recent ...

WebThe pharmacokinetics of cisplatin and its cytotoxic hydrolysis product cis-diammineaquachloroplatinum(II) ion (monohydrated complex) were investigated in seven patients after they received a 1-h infusion of cisplatin in normal saline at 100 mg/m2. The concentrations of intact cisplatin and the monoh … WebThe cisplatin hydrolysis products are more toxic than the parent drug itself. Sodium thiosulfate was successfully used to reduce toxic side effects of cisplatin hydrolysis products [7]. Because of the severe side effects, cisplatin is administrated in small doses at low concentrations. For these reasons, WebCisplatin, or cis-[Pt(NH3)2Cl2], was the first member of a new revolutionary class of anticancer drugs that is still used today for the … tsc cancer