Cisplatin cardiomyopathy

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August undefined, 2024

WebJun 23, 2014 · Cardiomyopathy after the use of gemcitabine monotherapy is extremely rare; and only one such case has been reported in detail previously. ... Barton C, Ghahramani P, Hirsh V: Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol. 2004, 15: 19-27. … WebAfter right heart catheterization, pathological results of a myocardial biopsy from the ventricular septum indicated no cardiac muscle hypertrophy, cardiac fibrosis, …

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WebDec 6, 2024 · weakness in the arms, hands, legs, or feet Less common Blood in the urine or stools difficult or labored breathing pinpoint red spots on the skin shortness of breath (severe) slow heartbeat tightness in the chest wheezing Incidence not known Anxiety blue lips, fingernails, or skin difficult or troubled breathing fainting fast heartbeat WebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP-induced cardiotoxicity. Wogonin is a natural flavonoid compound that possesses cardioprotective and anti-inflammatory qualities. diamondback comic book character

Cisplatin nephrotoxicity as a model of chronic kidney disease

WebOct 1, 2013 · Chemotherapy may induce entire spectrum of cardiac pathology. Cisplatin (CDDP) is a widely used chemotherapeutic agent and its use is limited by its wide range of toxicities, most common being renal and neurotoxicity. Cardiotoxicity of cisplatin is less common and may range from silent and symptomatic arrhythmias to cardiomyopathy … WebJan 1, 2013 · Patients receiving cisplatin-based chemotherapy may experience coronary artery diseases, arrhythmias, and cardiomyopathy 3). Moore et al. have reported cases of arterial thrombosis with subsequent ... WebJan 10, 2011 · Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that … diamondback consulting

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WebJul 23, 2024 · Clinical implication of Cisplatin (cis-dichlorodiammine-platinum (II), CP) is restricted owing to augmented oxidative stress and apoptosis that have been involved in cardiac injury. Cisplatin usage is also associated with the cardiotoxicity including arrhythmia, myocarditis, cardiomyopathy and congestive heart failure [1,2,3,4,5]. diamondback compounding pharmacy azWebCisplatin-induced cardiotoxicity is a well describe effect with a low incidence. Supraventricular arrhythmias and coro-nary artery disease are the main cardiac effects. ... Cardiotoxicity secondary to cisplatin administration manifests as both delayed effects (mainly as chronic ischemic cardiomyopathy and arterial hypertension) and acute ... circleoffset premium white

"WebJun 1, 2013 · Cardiotoxicity is a well known consequence of cancer chemotherapy. Cisplatin-based combinations are standard regimens in the therapy of advanced non-small cell lung cancer. Administration of cisplatin-containing chemotherapy causes significant oxidative and nitrosative stress in some patients. " - Cisplatin cardiomyopathy

Cisplatin cardiomyopathy

Gemcitabine-induced cardiomyopathy: a case report and review …

WebAcute clinical syndromes associated with cisplatin infusion include chest pain, palpitations, and, occasionally, elevated cardiac enzymes indicative of myocardial infarction (MI). 16 … WebFeb 21, 2024 · Among the serious complications that have been reported are: ● Arrhythmias ● Heart failure ● Myocardial necrosis causing a dilated cardiomyopathy

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WebCisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in … WebMar 12, 2015 · We previously demonstrated that the increase in troponin I (TnI) soon after high-dose chemotherapy (HDC) is a strong predictor of left ventricular dysfunction and poor cardiac outcome, particularly in patients showing a persistent TnI increase. 5,6 This finding has important clinical implications and allows the identification of patients at high risk of …

WebMay 4, 2024 · Signs and symptoms of dilated cardiomyopathy may include: Fatigue. Shortness of breath (dyspnea) during activity or while lying down. Reduced ability to exercise. Swelling (edema) in the legs, ankles, … WebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台

WebOct 11, 2024 · Weakening of the heart muscle (cardiomyopathy) Heart rhythm problems (arrhythmia) Heart attack Stroke High blood pressure Blood clots Whether you're at risk … WebCisplatin: 70 mg/m 2 IV: Dilute with 250 mL NS* and administer over 60 minutes. Do not administer with aluminum needles or sets. Day 2: Pretreatment considerations: Emesis …

WebFeb 2, 2024 · Learn about the potential side effects of pemetrexed. Includes common and rare side effects information for consumers and healthcare professionals.

WebThis table is provided as an example of how to administer this regimen; there may be other acceptable methods. This regimen must be administered by a clinician trained in the use of chemotherapy, who should use independent medical judgment in the context of individual circumstances to make adjustments, as necessary. circle of friends west bend wiWebOct 6, 2024 · The following are common signs of cardiomyopathy: Trouble breathing when you’re active or resting. Some people might also need to sleep sitting up or with many pillows under their head to help them … diamondback comfort pedalsWebJun 1, 2013 · Cisplatin-based combinations are standard regimens in the treatment of advanced non-small cell lung cancer, significantly improving survival of patients. … diamondback construction texasWebWARNING: CARDIOMYOPATHY, INFUSION REACTIONS, EMBRYO-FETAL TOXICITY, and PULMONARY TOXICITY See full prescribing information for complete boxed warning Cardiomyopathy: trastuzumab products can result in subclinical and clinical cardiac ... Cisplatin was administered at 80 mg/m on Day 1 and the circleoffsetWebJul 27, 2024 · Conventional doxorubicin: Treatment (in combination regimens with cisplatin, methotrexate, and vinblastine) of invasive and advanced bladder carcinoma. ... Pediatric patients are at increased risk for developing delayed cardiotoxicity; doxorubicin-induced cardiomyopathy impairs myocardial growth as pediatric patients mature, … circle offset premium white briefumschlagWebJan 10, 2011 · Combinations of cisplatin with other anticancer drugs as methotrexate, 5-fluorouracil, bleomycin and doxorubicin are associated with lethal cardiomyopathy ( … diamondback constructionWebMar 17, 2024 · Cardiotoxicity is defined as any heart injury (functional or structural) related to cancer treatment, taking into consideration chemotherapy, radiotherapy … circle of friends western springs